Hydrochloric Acid → HCID 68907650, compound

HRID 546535Notes

Reaction equation

HRID 546535 reaction equation
C([O:5][C:6]([NH:8][C@H:9]1[CH2:14][C@H:13]([C:15](=[O:17])[NH2:16])[CH2:12][CH2:11][C@H:10]1[NH:18][C:19]([C:21]1[NH:22][C:23]2[C:28]([CH:29]=1)=[CH:27][C:26]([Cl:30])=[CH:25][CH:24]=2)=[O:20])=O)(C)(C)C.Cl.[CH3:32][N:33]1[CH2:38][CH2:37][C:36]2[N:39]=[C:40](C([O-])=O)[S:41][C:35]=2[CH2:34]1.[Li+]>O1CCOCC1>[C:15]([C@@H:13]1[CH2:12][CH2:11][C@@H:10]([NH:18][C:19]([C:21]2[NH:22][C:23]3[C:28]([CH:29]=2)=[CH:27][C:26]([Cl:30])=[CH:25][CH:24]=3)=[O:20])[C@@H:9]([NH:8][C:6]([C:40]2[S:41][C:35]3[CH2:34][N:33]([CH3:32])[CH2:38][CH2:37][C:36]=3[N:39]=2)=[O:5])[CH2:14]1)(=[O:17])[NH2:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 23704331Lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylateHCID 68907162HCID 68907162, compound

Product 1

HCID 68907650HCID 68907650, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(1R*,2S*,4R*)-N2-(tert-Butoxycarbonyl)-4-carbamoyl-N1-[(5-chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine was treated with a 4N dioxane solution of hydrochloric acid and then condensed with lithium 5-methyl-4,5,6,7-tetrahydrothiazolo-[5,4-c]pyridine-2-carboxylate in a similar manner to Example 118 to obtain the title compound.

Sources & evidence

ORD record
ord-726ee4e824bd4e64ad6e3e6041dbf8cf
Source dataset
uspto-grants-2011_05
Patent number
US07935824B2

Reaction notes

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