Dimethylamine, hydrochloride → HCID 68905383, compound

HRID 546540Notes

Reaction equation

C(O[C:4]([C@H:6]1[CH2:11][CH2:10][C@H:9]([NH:12][C:13]([C:15]2[NH:16][C:17]3[C:22]([CH:23]=2)=[CH:21][C:20]([F:24])=[CH:19][CH:18]=3)=[O:14])[C@H:8]([NH:25][C:26]([C:28]2[S:29][C:30]3[CH2:31][N:32]([CH3:37])[CH2:33][CH2:34][C:35]=3[N:36]=2)=[O:27])[CH2:7]1)=[O:5])C.[ClH:38].[CH3:39][NH:40][CH3:41]>>[ClH:38].[F:24][C:20]1[CH:21]=[C:22]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15]([C:13]([NH:12][C@H:9]1[CH2:10][CH2:11][C@H:6]([C:4](=[O:5])[N:40]([CH3:41])[CH3:39])[CH2:7][C@H:8]1[NH:25][C:26]([C:28]1[S:29][C:30]3[CH2:31][N:32]([CH3:37])[CH2:33][CH2:34][C:35]=3[N:36]=1)=[O:27])=[O:14])=[CH:23]2

Participants

Reactant 2

HCID 10473Dimethylamine, hydrochloride

HCID 57864675HCID 57864675, compound

Product 1

HCID 68905383HCID 68905383, compound

Procedure

(1S,2R,4S)-4-Ethoxycarbonyl-N1-[(5-fluoroindol-2-yl)carbonyl]-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine was hydrolyzed and then subjected to a condensation reaction with dimethylamine hydrochloride in a similar manner to Example 157 to obtain the title compound.

Sources & evidence

ORD record: ord-0f0c25a6553c4fe9b93b76b61c497627
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07935824B2

Reaction notes

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