Hydrochloric Acid → HCID 67187113, compound

HRID 546542Notes

Reaction equation

HRID 546542 reaction equation
C([O:5][C:6]([NH:8][C@@H:9]1[CH2:14][C@@H:13]([C:15](=[O:21])[NH:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:12][CH2:11][C@@H:10]1[NH:22][C:23]([C:25]1[NH:26][C:27]2[C:32]([CH:33]=1)=[CH:31][C:30]([Cl:34])=[CH:29][CH:28]=2)=[O:24])=O)(C)(C)C.Cl.[CH3:36][N:37]1[CH2:42][CH2:41][C:40]2[N:43]=[C:44](C([O-])=O)[S:45][C:39]=2[CH2:38]1.[Li+]>O1CCOCC1>[ClH:34].[C:17]([NH:16][C:15]([C@H:13]1[CH2:12][CH2:11][C@H:10]([NH:22][C:23]([C:25]2[NH:26][C:27]3[C:32]([CH:33]=2)=[CH:31][C:30]([Cl:34])=[CH:29][CH:28]=3)=[O:24])[C@H:9]([NH:8][C:6]([C:44]2[S:45][C:39]3[CH2:38][N:37]([CH3:36])[CH2:42][CH2:41][C:40]=3[N:43]=2)=[O:5])[CH2:14]1)=[O:21])([CH3:18])([CH3:20])[CH3:19]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 23704331Lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylateHCID 58822083HCID 58822083, compound

Product 1

HCID 67187113HCID 67187113, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(1S,2R,4S)—N2-(tert-Butoxycarbonyl)-4-[N-(tert-butyl)carbamoyl]-N1-[(5-chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine was treated with a 4N dioxane solution of hydrochloric acid and then condensed with lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate in a similar manner to Example 118 to obtain the title compound.

Sources & evidence

ORD record
ord-7763657d65e84976ac870d69536d4b41
Source dataset
uspto-grants-2011_05
Patent number
US07935824B2

Reaction notes

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