Hydrochloric Acid → HCID 67056629, compound

HRID 546547Notes

Reaction equation

HRID 546547 reaction equation
C([O:5][C:6]([NH:8][C@@H:9]1[CH2:14][C@@H:13]([C:15](=[O:19])[N:16]([CH3:18])[CH3:17])[CH2:12][CH2:11][C@@H:10]1[NH:20][C:21]([C:23]1[NH:24][C:25]2[C:30]([CH:31]=1)=[C:29]([F:32])[CH:28]=[C:27]([Cl:33])[CH:26]=2)=[O:22])=O)(C)(C)C.[ClH:34].[CH3:35][N:36]1[CH2:41][CH2:40][C:39]2[N:42]=[C:43](C([O-])=O)[S:44][C:38]=2[CH2:37]1.[Li+]>O1CCOCC1>[ClH:33].[Cl:34][C:28]1[C:29]([F:32])=[C:30]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23]([C:21]([NH:20][C@H:10]1[CH2:11][CH2:12][C@H:13]([C:15](=[O:19])[N:16]([CH3:18])[CH3:17])[CH2:14][C@H:9]1[NH:8][C:6]([C:43]1[S:44][C:38]3[CH2:37][N:36]([CH3:35])[CH2:41][CH2:40][C:39]=3[N:42]=1)=[O:5])=[O:22])=[CH:31]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 23704331Lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylateHCID 86593067HCID 86593067, compound

Product 1

HCID 67056629HCID 67056629, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(1S,2R,4S)—N2-(tert-Butoxycarbonyl)-N1-[(6-chloro-4-fluoroindol-2-yl)carbonyl]-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine was treated with a 4N dioxane solution of hydrochloric acid and then condensed with lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate in a similar manner to Example 118 to obtain the title compound.

Sources & evidence

ORD record
ord-98b8579f85734273bd1d6bedbdd52fd0
Source dataset
uspto-grants-2011_05
Patent number
US07935824B2

Reaction notes

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