Hydrochloric Acid → HCID 67056776, compound

HRID 546548Notes

Reaction equation

HRID 546548 reaction equation
C([O:5][C:6]([NH:8][C@@H:9]1[CH2:14][C@@H:13]([C:15](=[O:19])[N:16]([CH3:18])[CH3:17])[CH2:12][CH2:11][C@@H:10]1[NH:20][C:21]([C:23]1[N:24]=[CH:25][C:26]2[C:31]([CH:32]=1)=[CH:30][CH:29]=[C:28]([Cl:33])[CH:27]=2)=[O:22])=O)(C)(C)C.Cl.[CH3:35][N:36]1[CH2:41][CH2:40][C:39]2[N:42]=[C:43](C([O-])=O)[S:44][C:38]=2[CH2:37]1.[Li+]>C(O)C>[ClH:33].[Cl:33][C:28]1[CH:27]=[C:26]2[C:31]([CH:32]=[C:23]([C:21]([NH:20][C@H:10]3[CH2:11][CH2:12][C@H:13]([C:15](=[O:19])[N:16]([CH3:17])[CH3:18])[CH2:14][C@H:9]3[NH:8][C:6]([C:43]3[S:44][C:38]4[CH2:37][N:36]([CH3:35])[CH2:41][CH2:40][C:39]=4[N:42]=3)=[O:5])=[O:22])[N:24]=[CH:25]2)=[CH:30][CH:29]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 23704331Lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylateHCID 58822109HCID 58822109, compound

Product 1

HCID 67056776HCID 67056776, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(1S,2R,4S)—N2-(tert-Butoxycarbonyl)-N1-[(7-chloroisoquinolin-3-yl)carbonyl]-4-(N,N-dimethyl-carbamoyl)-1,2-cyclohexanediamine was treated with a saturated ethanol solution of hydrochloric acid and then condensed with lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate in a similar manner to Example 118 to obtain the title compound.

Sources & evidence

ORD record
ord-b2517d083d9a42b99902f3e61fc45842
Source dataset
uspto-grants-2011_05
Patent number
US07935824B2

Reaction notes

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