Ammonia → HCID 57625970, compound

HRID 546552Notes

Reaction equation

HRID 546552 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15](=[O:16])[C:14]([CH3:18])([CH3:17])[N:13]([CH2:19][C:20]3[CH:25]=[CH:24][N:23]=[C:22](S(C)(=O)=O)[N:21]=3)[C:12]2=[O:30])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH3:31]>O1CCOCC1>[NH2:31][C:22]1[N:21]=[C:20]([CH2:19][N:13]2[C:14]([CH3:18])([CH3:17])[C:15](=[O:16])[N:11]([C:8]3[CH:9]=[CH:10][C:5]([C:1]([CH3:3])([CH3:2])[CH3:4])=[CH:6][CH:7]=3)[C:12]2=[O:30])[CH:25]=[CH:24][N:23]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 57625995HCID 57625995, compound

Product 1

HCID 57625970HCID 57625970, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 0.45 g of 3-(4-tert-butylphenyl)-5,5-dimethyl-1-{[2-(methylsulphonyl)pyrimidin-4-yl]methyl}imidazolidine-2,4-dione obtained in stage e) in 2.1 mL of dioxane and 2.1 mL of 30% aqueous ammonia is heated in a sealed microwave tube at 120° C. for 1 hour. After evaporating off the solvents, 0.38 g of 1-[(2-aminopyrimidin-4-yl)methyl]-3-(4-tert-butylphenyl)-5,5-dimethylimidazolidine-2,4-dione is obtained, the characteristics of which are as follows:

Workup

  1. customAfter evaporating off the solvents

Sources & evidence

ORD record
ord-471528e83cac4f7abb1d735f1ae2aec7
Source dataset
uspto-grants-2011_05
Patent number
US07935819B2

Reaction notes

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