Ammonia → HCID 57625970, compound

Participants

Reaction Steps

A solution of 0.45 g of 3-(4-tert-butylphenyl)-5,5-dimethyl-1-{[2-(methylsulphonyl)pyrimidin-4-yl]methyl}imidazolidine-2,4-dione obtained in stage e) in 2.1 mL of dioxane and 2.1 mL of 30% aqueous ammonia is heated in a sealed microwave tube at 120° C. for 1 hour. After evaporating off the solvents, 0.38 g of 1-[(2-aminopyrimidin-4-yl)methyl]-3-(4-tert-butylphenyl)-5,5-dimethylimidazolidine-2,4-dione is obtained, the characteristics of which are as follows:

Provenance & Evidence