反应详情

温度

75 °C

To a solution of 1.8 g of N-(4-{[3-(4-tert-butylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl]methyl}pyridin-2-yl)acetamide obtained in stage b) below in 40 mL of dioxane are added 20.8 mL of 1N hydrochloric acid solution. The mixture is heated at 75° C. for six hours, 42 mL of 1N hydrochloric acid solution are then added and stirring is continued for 36 hours at the same temperature. The solution is then concentrated under reduced pressure to give 1.4 g of 1-[(2-aminopyridin-4-yl)methyl]-3-(4-tert-butylphenyl)-5,5-dimethylimidazolidine-2,4-dione hydrochloride in the form of a white powder, the characteristics of which are as follows:

1. concentrationThe solution is then concentrated under reduced pressure