Hydrochloric Acid → 1-Amino-3-(3,4,5-trifluorophenyl)piperidin-2-one hydrochloride

Participants

Reaction Steps

A solution of 4 N hydrochloric acid in ethyl acetate (1 mL) was added to a solution of tert-butyl [2-oxo-3-(3,4,5-trifluorophenyl)piperidin-1-yl]carbamate (134 mg) in chloroform (1 mL), and the reaction solution was stirred at room temperature for three hours. The reaction solution was concentrated under reduced pressure to obtain 109 mg of the title compound. The property value of the compound is as follows.

Provenance & Evidence