Hydrochloric Acid → 1-Amino-3-(3,4,5-trifluorophenyl)piperidin-2-one hydrochloride

HRID 546668Notes

Reaction equation

HRID 546668 reaction equation
[ClH:1].[O:2]=[C:3]1[CH:8]([C:9]2[CH:14]=[C:13]([F:15])[C:12]([F:16])=[C:11]([F:17])[CH:10]=2)[CH2:7][CH2:6][CH2:5][N:4]1[NH:18]C(=O)OC(C)(C)C>C(OCC)(=O)C.C(Cl)(Cl)Cl>[ClH:1].[NH2:18][N:4]1[CH2:5][CH2:6][CH2:7][CH:8]([C:9]2[CH:10]=[C:11]([F:17])[C:12]([F:16])=[C:13]([F:15])[CH:14]=2)[C:3]1=[O:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86628505Tert-butyl[2-oxo-3-(3,4,5-trifluorophenyl)piperidin-1-yl]carbamate

Product 1

HCID 668393791-Amino-3-(3,4,5-trifluorophenyl)piperidin-2-one hydrochloride

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 4 N hydrochloric acid in ethyl acetate (1 mL) was added to a solution of tert-butyl [2-oxo-3-(3,4,5-trifluorophenyl)piperidin-1-yl]carbamate (134 mg) in chloroform (1 mL), and the reaction solution was stirred at room temperature for three hours. The reaction solution was concentrated under reduced pressure to obtain 109 mg of the title compound. The property value of the compound is as follows.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-e35641c369a24c5199398012af84500c
Source dataset
uspto-grants-2011_05
Patent number
US07935815B2

Reaction notes

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