Hydrogen Bromide → HCID 14719550, compound

HRID 54670Notes

Reaction equation

HRID 54670 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([CH:11]2[C:20]3[C:15](=[CH:16][C:17]([CH3:21])=[CH:18][CH:19]=3)[CH2:14][NH:13][CH2:12]2)[CH:6]=[CH:7][C:8]=1[O:9]C.[BrH:22]>>[BrH:22].[OH:2][C:3]1[CH:4]=[C:5]([CH:11]2[C:20]3[C:15](=[CH:16][C:17]([CH3:21])=[CH:18][CH:19]=3)[CH2:14][NH:13][CH2:12]2)[CH:6]=[CH:7][C:8]=1[OH:9]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 10802931HCID 10802931, compound

Product 1

HCID 14719550HCID 14719550, compound

Procedure

850 mg of 4-(3,4-dimethoxyphenyl)-7-methyl-1,2,3,4-tetrahydroisoquinoline was dissolved in 17 ml of 48% hydrobromic acid, and the mixture was heated under reflux under an argon gas stream for 3 hours. The reaction solution was cooled, and the crystals obtained were collected by filtration, giving 620 mg of 4-(3,4-dihydroxyphenyl)-7-methyl-1,2,3,4-tetrahydroisoquinoline, hydrobromide.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux under an argon gas stream for 3 hours
  3. temperatureThe reaction solution was cooled
  4. customthe crystals obtained
  5. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-8012078b78964463921764408186b656
Source dataset
uspto-grants-1997_04
Patent number
US05623074

Reaction notes

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