Hydrochloric Acid → 1-Aminopiperidin-2-one hydrochloride

HRID 546702Notes

Reaction equation

HRID 546702 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[NH:8]C(=O)OC(C)(C)C.[ClH:16]>O1CCOCC1>[ClH:16].[NH2:8][N:3]1[CH2:4][CH2:5][CH2:6][CH2:7][C:2]1=[O:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 17896840tert-Butyl (2-oxopiperidin-1-yl)carbamate

Product 1

HCID 668394931-Aminopiperidin-2-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl (2-oxopiperidin-1-yl)carbamate (129 mg) was dissolved in a solution of 4 N hydrogen chloride in dioxane (2 ml), and the reaction solution was stirred at room temperature for one hour. The reaction solution was concentrated under reduced pressure to obtain 92 mg of the title compound. The property values of the compound are as follows.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-61c0157fde1d4ffe88e296abae8c1cdd
Source dataset
uspto-grants-2011_05
Patent number
US07935815B2

Reaction notes

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