反应详情

温度

100 °C

Cesium carbonate (20.5 g), potassium iodide (521 mg) and chloroacetone (5.0 mL) were added to a solution of N-(6-chloro-2-methoxypyridin-3-yl)formamide (5.85 g) in DMF (34.3 mL), and the reaction solution was stirred at 100° C. for one hour. Ice water and chloroform were added to the reaction solution, and the organic layer was separated. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent: heptane-ethyl acetate system) to obtain 4.71 g of the title compound. The property value of the compound is as follows.

1. customthe organic layer was separated
2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified by silica gel column chromatography (elution solvent: heptane-ethyl acetate system)