反应详情

温度

100 °C

DMF (52 mL) was added to the 6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine (13.0 g, 48.5 mmol) and the tert-Butyl 2-acryloylhydrazinecarboxylate (9.9 g, 53.3 mmol) at room temperature under nitrogen atmosphere, And the mixture was stirred at 50° C. for 10 minutes. Tri(o-tolyl)phosphine (885 mg, 2.90 mmol), Palladium (II) acetate (327 mg, 1.45 mmol) and N,N-diisopropylethylamine (12.7 mL, 72.7 mmol) were added to the mixture, and the reaction mixture was stirred at 100° C. for 4 hours. The reaction mixture was cooled to room temperature and filtrated through Celite. The residue was washed twice with DMF (6 mL). Water (104 mL) was added dropwise to the filtrate at room temperature over 10 minutes. The mixture was stirred at room temperature for 15 hours. After the mixture was filtrated, the residue was washed with water/DMF=2:1 (30 mL) and MTBE (30 mL). The obtained solid was suspended in MTBE (50 mL) at room temperature for 2 hours, filtrated and dried under the reduced pressure to obtain the title compound (15.8 g, 87% yield).

1. temperatureThe reaction mixture was cooled to room temperature
2. filtrationfiltrated through Celite
3. washThe residue was washed twice with DMF (6 mL)
4. additionWater (104 mL) was added dropwise to the filtrate at room temperature over 10 minutes
5. stirringThe mixture was stirred at room temperature for 15 hours
6. filtrationAfter the mixture was filtrated
7. washthe residue was washed with water/DMF=2:1 (30 mL) and MTBE (30 mL)
8. waitThe obtained solid was suspended in MTBE (50 mL) at room temperature for 2 hours
9. filtrationfiltrated
10. customdried under the reduced pressure