反应详情

Trifluoroacetic acid (0.14 mL) was added to a solution of {5-[4-(1-{4-[3-(t-butyl-dimethyl-silanyloxy)-4,4-dimethyl-pentyl]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenyl]-pyridin-3-yl}-acetic acid methyl ester (Example 24-(3); 15.4 mg, 0.0244 mmol) in dichloromethane (0.7 mL) at room temperature, and the mixture was stirred at room temperature for one hour and 15 minutes. The solvent in the reaction solution was distilled off under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate=1/1 to 1/2) to give the title compound (11.6 mg, 92%).

1. distillationThe solvent in the reaction solution was distilled off under reduced pressure
2. customThe residue was purified by silica gel chromatography (hexane/ethyl acetate=1/1 to 1/2)