反应详情

Potassium carbonate (59.7 mg, 0.43 mmol) and 1-chloropinacolin (42.0 mg, 0.31 mmol) were added to a solution of trifluoromethanesulfonic acid 4-[1-ethyl-1-(4-hydroxy-3-methyl-phenyl)-propyl]-2-methyl-phenyl ester (Example 1-(1); 0.1 g, 0.24 mmol) in acetone (1.2 mL), and the mixture was heated under reflux for 17 hours. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (6% ethyl acetate/hexane) to give the title compound (103.5 mg, 83%).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 17 hours
3. filtrationThe reaction mixture was filtered
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThe residue was purified by silica gel chromatography (6% ethyl acetate/hexane)