HRID546863

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCC(CC)(c1ccc(C#CC2(O[Si](C)(C)C)CCCC2)c(C)c1)c1ccc(B2OC(C)(C)C(C)(C)O2)c(C)c1

HCID57708976

未命名化合物

PRODUCTS

生成物

HCID57708996

未命名化合物

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID178418390

未命名化合物

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

10% palladium carbon (40 mg) was added to a solution of 2-(4-{1-ethyl-1-[3-methyl-4-(1-trimethylsilanyloxy-cyclopentylethynyl)-phenyl]-propyl}-2-methyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (Example 32-(4); 0.26 g, 0.48 mmol) in ethyl acetate (2.5 mL), and the mixture was stirred under hydrogen charging for three hours. The reaction mixture was filtered and concentrated to give the title compound (0.26 g, 100%).

WORKUP

后处理

filtrationThe reaction mixture was filtered
concentrationconcentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f3d3352e3d3b459c8bbc1098f179f921
来源数据集: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07935688B2
来源说明: uspto-grants-2011_05

反应 SMILES

[CH2:1]([C:3]([C:25]1[CH:30]=[CH:29][C:28]([B:31]2[O:35][C:34]([CH3:37])([CH3:36])[C:33]([CH3:39])([CH3:38])[O:32]2)=[C:27]([CH3:40])[CH:26]=1)([C:6]1[CH:11]=[CH:10][C:9]([C:12]#[C:13][C:14]2([O:19][Si:20]([CH3:23])([CH3:22])[CH3:21])[CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:8]([CH3:24])[CH:7]=1)[CH2:4][CH3:5])[CH3:2]>C(OCC)(=O)C.[C].[Pd]>[CH2:1]([C:3]([C:25]1[CH:30]=[CH:29][C:28]([B:31]2[O:32][C:33]([CH3:39])([CH3:38])[C:34]([CH3:36])([CH3:37])[O:35]2)=[C:27]([CH3:40])[CH:26]=1)([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][C:14]2([O:19][Si:20]([CH3:23])([CH3:22])[CH3:21])[CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:8]([CH3:24])[CH:7]=1)[CH2:4][CH3:5])[CH3:2]