Hydrochloric Acid → HCID 67721738, compound

HRID 54688Notes

Reaction equation

HRID 54688 reaction equation
C([N:4]1[CH2:13][C@H:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20]C)=[C:16]([O:22]C)[CH:15]=2)[C:11]2[C:6](=[C:7]([O:26]C)[C:8]([O:24]C)=[CH:9][CH:10]=2)[CH2:5]1)(=[O:3])C.[ClH:28]>C(O)C>[OH2:3].[ClH:28].[OH:24][C:8]1[C:7]([OH:26])=[C:6]2[C:11]([C@@H:12]([C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[C:16]([OH:22])[CH:15]=3)[CH2:13][NH:4][CH2:5]2)=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54226046(R)-(-)-N-acetyl-7,8-dimethoxy-4-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 67721738HCID 67721738, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(i) To 1.15 g of (R)-(+)-N-acetyl-7,8-dihydroxy-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline 1/4 hydrate were added 9 ml of 3N hydrochloric acid and 9 ml of ethanol, and the mixture was heated under an argon gas stream for 24 hours. After the reaction solution was cooled, the crystals which separated out were collected by filtration, affording 1.09 g of (R)-(+)-7,8-dihydroxy-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride monohydrate.

Workup

  1. temperaturethe mixture was heated under an argon gas stream for 24 hours
  2. temperatureAfter the reaction solution was cooled
  3. customthe crystals which separated out
  4. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-7ea080331a9f4b34b887931f635af00e
Source dataset
uspto-grants-1997_04
Patent number
US05623074

Reaction notes

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