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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 54689Generated: October 29, 2026

Phenacyl bromide → 2-(2-Hydroxyethylamino)-1-phenacylbenzimidazole dihydrobromide

https://huagongshe.com/reaction/54689

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenacyl bromideHCID 6259—
Reactant2-((1H-1,3-benzodiazol-2-yl)amino)ethan-1-olHCID 583867—
SolventIsopropanolHCID 3776—
Product2-(2-Hydroxyethylamino)-1-phenacylbenzimidazole dihydrobromideHCID 1904080089%

Reaction Steps

Heat at reflux for three hours 8.95 g (50 mmol) of 2-(2-hydroxyethylamino)benzimidazole and 10 g of phenacyl bromide in 100 ml of 2-propanol. Allow to cool. Suction-filter the resulting precipitate and wash with acetone. The title compound is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05623073
Source datasetuspto-grants-1997_04
ORD IDord-6a76d4a93fea4c46b3f99c791933bc4f
Source noteuspto-grants-1997_04