Ammonium Hydroxide → 2-{2-[(2-hydroxyethyl)amino]-1H-benzimidazol-1-yl}-1-phenylethanone

HRID 54690Notes

Reaction equation

HRID 54690 reaction equation
[OH-].[NH4+].Br.Br.[OH:5][CH2:6][CH2:7][NH:8][C:9]1[N:13]([CH2:14][C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:16])[C:12]2[CH:23]=[CH:24][CH:25]=[CH:26][C:11]=2[N:10]=1>>[OH:5][CH2:6][CH2:7][NH:8][C:9]1[N:13]([CH2:14][C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:16])[C:12]2[CH:23]=[CH:24][CH:25]=[CH:26][C:11]=2[N:10]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 190408002-(2-Hydroxyethylamino)-1-phenacylbenzimidazole dihydrobromide

Product 1

HCID 28501002-{2-[(2-hydroxyethyl)amino]-1H-benzimidazol-1-yl}-1-phenylethanone

Procedure

Add 22% ammonium hydroxide to 75 ml of a hot solution of the dihydrobromide obtained in Step A in 95° alcohol until a pH of approximately 10 is obtained. The title compound precipitates and is filtered, washed with water and dried.

Workup

  1. customis obtained
  2. customThe title compound precipitates
  3. filtrationis filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-31389e86c4f54555a7926b88794f66ba
Source dataset
uspto-grants-1997_04
Patent number
US05623073

Reaction notes

Loading…