Formaldehyde → HCID 19040835, compound

HRID 54700Notes

Reaction equation

HRID 54700 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[N:8]([CH:9]=1)[C:7]1[CH:10]=[C:11]([CH3:15])[C:12]([CH3:14])=[CH:13][C:6]=1[N:5]2[CH2:16][CH3:17].[CH2:18]=O.[CH2:20]([NH:22][CH2:23][CH3:24])[CH3:21]>C(O)C>[CH2:20]([N:22]([CH2:18][C:9]1[N:8]2[C:4]([N:5]([CH2:16][CH3:17])[C:6]3[CH:13]=[C:12]([CH3:14])[C:11]([CH3:15])=[CH:10][C:7]=32)=[N:3][C:2]=1[CH3:1])[CH2:23][CH3:24])[CH3:21]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 8021DiethylamineHCID 19040803HCID 19040803, compound

Product 1

HCID 19040835HCID 19040835, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1.5 g (6.5 mmol) of 2,6,7-trimethyl-9-ethylimidazo[1,2-a]benzimidazole in 8 ml of ethanol is mixed with 0.6 ml (7.5 mmol) of 40% formaldehyde and diethylamine (0.76 ml, 7.5 mmol). Stir at room temperature. Once the reaction is complete (verified by thin- layer chromatography), evaporate, wash the residue with water, dry, and recrystallise from petroleum ether.

Workup

  1. customevaporate
  2. washwash the residue with water
  3. customdry
  4. customrecrystallise from petroleum ether

Sources & evidence

ORD record
ord-bec9709a1d8b408e9dc23c1157de5d58
Source dataset
uspto-grants-1997_04
Patent number
US05623073

Reaction notes

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