3-Amino-1-propanol → 3-(1H-Benzimidazol-2-ylamino)-1-propanol

HRID 54705Notes

Reaction equation

HRID 54705 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1S(O)(=O)=O.[NH2:14][CH2:15][CH2:16][CH2:17][OH:18]>O>[OH:18][CH2:17][CH2:16][CH2:15][NH:14][C:2]1[NH:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[N:1]=1

Participants

4

Reactant 2

HCID 90863-Amino-1-propanolHCID 15721601H-Benzimidazole-2-sulfonic acid

Product 1

HCID 20033253-(1H-Benzimidazol-2-ylamino)-1-propanol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

Heat at 145°-150° C. for two hours a mixture of 5 g (25 mmol) of 2-benzimidazolesulfonic acid and 5.7 ml (75 mmol) of 3-aminopropanol. Cool to 90° C. and add 15 ml of cold water, with vigorous stirring, until a precipitate is formed. Maintain at a temperature of approximately 4° C. for one night, filter the title compound precipitate, wash with cold water and dry.

Workup

  1. temperatureHeat at 145°-150° C. for two hours
  2. customwith vigorous stirring, until a precipitate is formed
  3. temperatureMaintain at a temperature of approximately 4° C. for one night
  4. filtrationfilter the title compound precipitate
  5. washwash with cold water
  6. customdry

Sources & evidence

ORD record
ord-5077926056874e3dabe695ed6565d129
Source dataset
uspto-grants-1997_04
Patent number
US05623073

Reaction notes

Loading…