反应详情

A solution of trimethylsilyldiazomethane in hexane (2 M, 1.5 mL, 3.0 mmol) was added to a solution of (R)-(3-chloro-phenyl)hydroxy-acetic acid (497 mg, 2.66 mmol) in benzene (2.6 mL)-methanol (1.3 mL) under cooling with ice. Then, the ice bath was removed and the mixture was stirred at room temperature for five minutes. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate=3/1) to give the title compound (533 mg, 100%).

1. temperatureunder cooling with ice
2. customThen, the ice bath was removed
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. customThe residue was purified by silica gel chromatography (hexane/ethyl acetate=3/1)