反应详情

温度

140 °C

A 4 N hydrochloric acid aqueous solution (0.80 mL) was added to a solution of the mixture containing (S)-amino-(4′-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2′-methyl-biphenyl-4-yl)-acetic acid methyl ester (220 mg) in acetone (0.60 mL), and the mixture was stirred with microwave heating at 140° C. for 10 minutes. The reaction mixture was purified by high performance liquid chromatography (GL Sciences Inertsil ODS-3, 20 mm I.D.×150 mm, methanol:water=20:80 to 100:0, 20 mL/min) and concentrated under reduced pressure to give the target compound as a white solid (14.0 mg, 36% in two steps).

1. customThe reaction mixture was purified by high performance liquid chromatography (GL Sciences Inertsil ODS-3, 20 mm I.D.×150 mm, methanol:water=20:80 to 100:0, 20 mL/min)
2. concentrationconcentrated under reduced pressure