Sodium Hydroxide → HCID 57443585, compound

HRID 547158Notes

Reaction equation

HRID 547158 reaction equation
[OH-].[Na+:2].C([O:5][C:6](=[O:41])[CH2:7][C:8]1[CH:13]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([CH2:38][CH3:39])([C:23]3[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][CH:31]([OH:36])[C:32]([CH3:35])([CH3:34])[CH3:33])=[C:25]([CH3:37])[CH:24]=3)[CH2:21][CH3:22])=[CH:16][C:15]=2[CH3:40])[N:11]=[N:10][CH:9]=1)C>CO>[CH2:21]([C:20]([C:17]1[CH:18]=[CH:19][C:14]([C:12]2[N:11]=[N:10][CH:9]=[C:8]([CH2:7][C:6]([O-:41])=[O:5])[CH:13]=2)=[C:15]([CH3:40])[CH:16]=1)([C:23]1[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][CH:31]([OH:36])[C:32]([CH3:34])([CH3:35])[CH3:33])=[C:25]([CH3:37])[CH:24]=1)[CH2:38][CH3:39])[CH3:22].[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57443580HCID 57443580, compound

Product 1

HCID 57443585HCID 57443585, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 0.25 N sodium hydroxide aqueous solution (0.060 mL) was added to a solution of [6-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2-methyl-phenyl)-pyridazin-4-yl]acetic acid ethyl ester (Example 183-(4); 6.5 mg, 0.012 mmol) in methanol (0.20 mL) at room temperature, and the mixture was stirred at room temperature for four hours. The reaction mixture was concentrated under reduced pressure to give the title compound (6.5 mg, 100%).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-7e59e7c661aa4501ad462bcbeddcfac2
Source dataset
uspto-grants-2011_05
Patent number
US07935688B2

Reaction notes

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