3-Amino-1-propanol → HCID 22478308, compound

HRID 547228Notes

Reaction equation

HRID 547228 reaction equation
[C:1]1(=[O:8])[O:7][C:5](=O)[CH2:4][O:3][CH2:2]1.[NH2:9][CH2:10][CH2:11][CH2:12][OH:13]>>[OH:13][CH2:12][CH2:11][CH2:10][N:9]1[C:1](=[O:8])[CH2:2][O:3][CH2:4][C:5]1=[O:7]

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 782321,4-Dioxane-2,6-dione

Product 1

HCID 22478308HCID 22478308, compoundYield 99%

Procedure

A solution of diglycolic anhydride (2.32 g, 20 mmol) in 3-amino-1-propanol (6 ml) was refluxed at 180° C. for 3 hours. The volatiles were removed by evaporation and the residue was purified by column chromatography on silica eluting with methylene chloride/methanol (8/2) to give 4-(3-hydroxypropyl)-3,5-dioxomorpholine (3.46 g, 99%).

Workup

  1. customThe volatiles were removed by evaporation
  2. customthe residue was purified by column chromatography on silica eluting with methylene chloride/methanol (8/2)

Sources & evidence

ORD record
ord-6aa4f29509fb4d7c80826b8d25fd3a59
Source dataset
uspto-grants-2011_05
Patent number
USRE042353E1

Reaction notes

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