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HRID547273

反应详情

EQUATION

反应方程式

HRID 547273 的结构方程式

REACTANTS

反应物

2
结构：O=C1CCC(=O)N1Br
HCID67184

1-Bromopyrrolidine-2,5-dione

C4H4BrNO2

结构：CC(=O)c1ccc(C)c(Cl)n1
HCID72214045

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)c1ccc(CBr)c(Cl)n1
HCID86011816

Ethanone, 1-[5-(bromomethyl)-6-chloro-2-pyridinyl]-

C8H7BrClNO

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClC(Cl)(Cl)Cl
溶剂HCID5943

Carbon tetrachloride

CCl4

PROCEDURE

实验过程

To a solution of 1-(6-chloro-5-methyl-pyridin-2-yl)-ethanone (1 eq) in CCl4 is added NBS (1 eq) and BPO (0.1 eq). The mixture is refluxed for 12 hours. After concentration, 1-(5-bromomethyl-6-chloro-pyridin-2-yl)-ethanone is isolated by flash column chromatography. MS: (ES+): 247.9 (M+1)+.

WORKUP

后处理

  1. temperatureThe mixture is refluxed for 12 hours
  2. concentrationAfter concentration