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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 547273Generated: October 25, 2026

N-bromobutanimide → Ethanone, 1-[5-(bromomethyl)-6-chloro-2-pyridinyl]-

https://huagongshe.com/reaction/547273

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-bromobutanimideHCID 67184—
Reactant1-(6-Chloro-5-methylpyridin-2-YL)ethanoneHCID 72214045—
SolventCarbon TetrachlorideHCID 5943—
ProductEthanone, 1-[5-(bromomethyl)-6-chloro-2-pyridinyl]-HCID 86011816—

Reaction Steps

To a solution of 1-(6-chloro-5-methyl-pyridin-2-yl)-ethanone (1 eq) in CCl4 is added NBS (1 eq) and BPO (0.1 eq). The mixture is refluxed for 12 hours. After concentration, 1-(5-bromomethyl-6-chloro-pyridin-2-yl)-ethanone is isolated by flash column chromatography. MS: (ES+): 247.9 (M+1)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07939519B2
Source datasetuspto-grants-2011_05
ORD IDord-40b4b35627e54876a317bd41d345991f
Source noteuspto-grants-2011_05