反应详情

To a suspension of 5-mercaptoimidazo[1,2-a]pyridine (150 mg, 1 mmole) and 2-[2-(bromo)ethyl]isoindolin-1-one (240 mg, 1 mmole) in ethanol (15 ml) was added triethylamine (0.21 ml, 1.5 mmoles) and the mixture Was stirred at room temperature for 12 hours and heated at reflux for 2 hours. After the solvent was distilled off, chloroform was added to the residue which was washed with water and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was purified by column chromatography [eluent: ethyl acetate/ethanol (15:1)] to obtain 238 mg of the desired product (77.0%, light brown solid).

1. temperatureheated
2. temperatureat reflux for 2 hours
3. distillationAfter the solvent was distilled off
4. additionchloroform was added to the residue which
5. washwas washed with water
6. dry with materialdried over anhydrous magnesium sulfate
7. distillationAfter the solvent was distilled off
8. customthe residue was purified by column chromatography [eluent: ethyl acetate/ethanol (15:1)]