N-(2-hydroxy-2-methylpropyl)-3-nitro[1,5]naphthyridin-4-amine → 1,1-Dimethyl-2-[(3-amino[1,5]naphthyridin-4-yl)amino]ethanol

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Reaction Steps

N-(2-Hydroxy-2-methylpropyl)-3-nitro[1,5]naphthyridin-4-amine (44.12 g, 0.17 mol), 5% platinum on carbon (4.4 g) and isopropanol (890 mL) were combined in a Parr vessel and placed under hydrogen pressure (35 psi, 2.4×105 Pa) overnight. The reaction mixture was filtered through a layer of filtering agent. The layer of filtering agent was rinsed well with isopropanol. The filtrate was concentrated under reduced pressure to provide N4-(2-hydroxy-2-methylpropyl)[1,5]naphthyridin-3,4-diamine as a thick oil.

Provenance & Evidence