反应详情

N-(2-Hydroxy-2-methylpropyl)-3-nitro[1,5]naphthyridin-4-amine (44.12 g, 0.17 mol), 5% platinum on carbon (4.4 g) and isopropanol (890 mL) were combined in a Parr vessel and placed under hydrogen pressure (35 psi, 2.4×105 Pa) overnight. The reaction mixture was filtered through a layer of filtering agent. The layer of filtering agent was rinsed well with isopropanol. The filtrate was concentrated under reduced pressure to provide N4-(2-hydroxy-2-methylpropyl)[1,5]naphthyridin-3,4-diamine as a thick oil.

1. custompressure (35 psi, 2.4×105 Pa) overnight
2. filtrationThe reaction mixture was filtered through a layer
3. filtrationof filtering agent
4. filtrationThe layer of filtering agent
5. washwas rinsed well with isopropanol
6. concentrationThe filtrate was concentrated under reduced pressure