Triethylamine → Ethyl 1-[2-(4-hydroxyphenoxy)ethyl]piperidine-4-carboxylate

HRID 547352ノート

反応式

HRID 547352 の反応式
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.[NH:12]1[CH2:22][CH2:21][CH:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:14][CH2:13]1.CCN(CC)CC>CC#N>[OH:11][C:8]1[CH:9]=[CH:10][C:5]([O:4][CH2:3][CH2:2][N:12]2[CH2:22][CH2:21][CH:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:14][CH2:13]2)=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 70770Ethyl 4-piperidinecarboxylateHCID 128339324-(2-Bromoethoxy)phenol

生成物 1

HCID 57448391Ethyl 1-[2-(4-hydroxyphenoxy)ethyl]piperidine-4-carboxylate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a stirred suspension of 4-(2-bromo-ethoxy)-phenol (600 mg, 2.77 mmol) and ethyl isonipecotate (470 μL, 3.06 mmol) in CH3CN (12 mL) was added Et3N (768 μL, 5.54 mmol). The resultant mixture was stirred at rt overnight and then concentrated to afford the title compound, which was used immediately in the next step. MS (ESI): mass calcd. for C16H23NO4, 293.16; m/z found, 294.1 [M+H]+.

後処理

  1. concentrationconcentrated

出典と根拠

ORDレコード
ord-6b5970e75c0b4eb69c83f7c71f321063
出典データセット
uspto-grants-2011_05
特許番号
US07939527B2

反応ノート

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