Hydrochloric Acid → 5-[2-(Amino)ethylthio]-3-nitroimidazo[1,2-a]pyridine,dihydrochloride

HRID 5474Notes

Reaction equation

HRID 5474 reaction equation
C(OC([NH:8][CH2:9][CH2:10][S:11][C:12]1[N:17]2[C:18]([N+:21]([O-:23])=[O:22])=[CH:19][N:20]=[C:16]2[CH:15]=[CH:14][CH:13]=1)=O)(C)(C)C.[ClH:24]>CO>[ClH:24].[ClH:24].[NH2:8][CH2:9][CH2:10][S:11][C:12]1[N:17]2[C:18]([N+:21]([O-:23])=[O:22])=[CH:19][N:20]=[C:16]2[CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23362929HCID 23362929, compound

Product 1

HCID 200866515-[2-(Amino)ethylthio]-3-nitroimidazo[1,2-a]pyridine,dihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 5-[2-(tert-butoxycarbonylamino)ethylthio]-3-nitroimidazo[1,2-a]pyridine (364 mg, 1.08 mmoles) in methanol (3 ml) was added conc. hydrochloric acid (2 ml) and the mixture was stirred at room temperature for 1 hour. Then, the solvent was distilled off to obtain 340 mg of the desired product (quantitative, brown solid).

Workup

  1. distillationThen, the solvent was distilled off

Sources & evidence

ORD record
ord-9476683574db42fea1b85ced5bf91a51
Source dataset
uspto-grants-1993_09
Patent number
US05244908

Reaction notes

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