4-Bromophenol → 4-(2-(4-Bromophenoxy)ethyl)morpholine

HRID 547407Notes

Reaction equation

HRID 547407 reaction equation
Cl[CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1.[Br:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1>>[Br:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:2][CH2:3][N:4]2[CH2:9][CH2:8][O:7][CH2:6][CH2:5]2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 78084-BromophenolHCID 767274-(2-Chloroethyl)morpholine

Product 1

HCID 20538154-(2-(4-Bromophenoxy)ethyl)morpholine

Procedure

reacting 4-(2-chloroethyl)morpholine with 4-bromophenol to yield 4-(2-(4-bromophenoxy)ethyl)morpholine; (2) coupling 4-(2-(4-bromophenoxy)ethyl)morpholine with 6-fluoropyridin-3-yl-3-boronic acid to yield 4-(2-(4-(6-fluoropyridin-3-yl)phenoxy)ethyl)morpholine;

Sources & evidence

ORD record
ord-9f525c584f54493386fb0e3ade613d9e
Source dataset
uspto-grants-2011_05
Patent number
US07939529B2

Reaction notes

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