反应详情

A solution of 3,4,4-trifluoro-3-butene-1-amine (2.25 g, 0. 018 mole) and 4,5-dihydro-5-oxo-1H-pyrazole-4-carboxaldehyde (1.12 g 0.01 mole) in absolute ethanol (30 mL) is heated at reflux for 15 min. The solution is concentrated and the residue is recrystallized from ether/dichloromethane to give 1.49 g of the title compound as an yellow solid, a 68% yield. m.p. 126°-130° C.

1. temperatureat reflux for 15 min
2. concentrationThe solution is concentrated
3. customthe residue is recrystallized from ether/dichloromethane