HCID 67201906, compound → HCID 44193195, compound

HRID 547476Notes

Reaction equation

HRID 547476 reaction equation
C([Si](C)(C)[O:6][CH2:7][CH2:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([C:18]2[N:19]=[C:20]3[C:26]([C:27](=[O:32])[C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:25][N:24](COCC[Si](C)(C)C)[C:21]3=[N:22][CH:23]=2)=[CH:10]1)(C)(C)C>CO>[OH:6][CH2:7][CH2:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([C:18]2[N:19]=[C:20]3[C:26]([C:27](=[O:32])[C:28]([CH3:30])([CH3:29])[CH3:31])=[CH:25][NH:24][C:21]3=[N:22][CH:23]=2)=[CH:10]1

Participants

3

Reactant 1

HCID 67201906HCID 67201906, compound

Product 1

HCID 44193195HCID 44193195, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-{2-[1-(2-Hydroxy-ethyl)-1H-indol-3-yl]-5H-pyrrolo[2,3-b]pyrazin-7-yl}-2,2-dimethyl-propan-1-one was prepared following the same procedure but using 1-[2-{1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-indol-3-yl}-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one as starting material. The product was obtained in 67% by trituration in MeOH.

Sources & evidence

ORD record
ord-e279fe62c20f4c2884e1b0fc5ad776e9
Source dataset
uspto-grants-2011_05
Patent number
US07939531B2

Reaction notes

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