HCID 67203342, compound → HCID 57829614, compound

HRID 547477Notes

Reaction equation

HRID 547477 reaction equation
[CH3:1][C:2]([CH3:41])([CH3:40])[C:3]([C:5]1[C:13]2[C:8](=[N:9][CH:10]=[C:11]([C:14]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[N:16]([CH2:23][CH2:24][N:25]4[CH2:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]4)[CH:15]=3)[N:12]=2)[N:7](COCC[Si](C)(C)C)[CH:6]=1)=[O:4]>C(Cl)Cl>[CH3:1][C:2]([CH3:41])([CH3:40])[C:3]([C:5]1[C:13]2[C:8](=[N:9][CH:10]=[C:11]([C:14]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[N:16]([CH2:23][CH2:24][N:25]4[CH2:26][CH2:27][N:28]([CH3:31])[CH2:29][CH2:30]4)[CH:15]=3)[N:12]=2)[NH:7][CH:6]=1)=[O:4]

Participants

3

Reactant 1

HCID 67203342HCID 67203342, compound

Product 1

HCID 57829614HCID 57829614, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

2,2-Dimethyl-1-(2-{1-[2-(4-methyl-piperazin-1-yl)-ethyl]-1H-indol-3-yl}-5H-pyrrolo[2,3-b]pyrazin-7-yl)-propan-1-one was prepared following a similar procedure but using 2,2-dimethyl-1-[2-{1-[2-(4-methyl-piperazin-1-yl)-ethyl]-1H-indol-3-yl}-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-propan-1-one as starting material. The product was isolated in 75% yield by SiO2 chromatography (DCM/[DCM/MeOH/NH4OH 60/10/1] 100-75% DCM).

Sources & evidence

ORD record
ord-fd184f2de0444912b585b846d4dfa9a1
Source dataset
uspto-grants-2011_05
Patent number
US07939531B2

Reaction notes

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