Sodium Hydroxide → HCID 16128759, compound

HRID 547593Notes

Reaction equation

HRID 547593 reaction equation
C[O:2][C:3]([C:5]1[N:6]=[CH:7][N:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=2)[CH:9]=1)=[O:4].[OH-].[Na+]>CO>[N+:16]([C:12]1[CH:11]=[C:10]([N:8]2[CH:9]=[C:5]([C:3]([OH:4])=[O:2])[N:6]=[CH:7]2)[CH:15]=[CH:14][CH:13]=1)([O-:18])=[O:17]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 16128758HCID 16128758, compound

Product 1

HCID 16128759HCID 16128759, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
70 °C

Procedure

1-(3-Nitro-phenyl)-1H-imidazole-4-carboxylic acid methyl ester 20 (0.7 g; 2.8 mmol) was suspended in MeOH (15 mL) and 2N NaOH aq. (2 mL) was added. The mixture was stirred at 70° C. for 16 h. The MeOH was evaporated and the product was isolated by suction filtration, washed with water and dried under vacuum to afford 0.56 g (86%) of 21 as an off-white solid. HRMS (ESI+): m/z=233.1823 [M+H]

Workup

  1. customThe MeOH was evaporated
  2. customthe product was isolated by suction filtration
  3. washwashed with water
  4. customdried under vacuum

Sources & evidence

ORD record
ord-e686e9012a0142f7b1de021d2b70232e
Source dataset
uspto-grants-2011_05
Patent number
US07939556B2

Reaction notes

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