Sodium Hydroxide → HCID 16128759, compound

Participants

Reaction Conditions

Reaction Steps

1-(3-Nitro-phenyl)-1H-imidazole-4-carboxylic acid methyl ester 20 (0.7 g; 2.8 mmol) was suspended in MeOH (15 mL) and 2N NaOH aq. (2 mL) was added. The mixture was stirred at 70° C. for 16 h. The MeOH was evaporated and the product was isolated by suction filtration, washed with water and dried under vacuum to afford 0.56 g (86%) of 21 as an off-white solid. HRMS (ESI+): m/z=233.1823 [M+H]

Provenance & Evidence