反应详情

To a mixture of 3,3-dimethylcyclohexanone (4.0 g, 0.032 mol) and hydroxylamine hydrochloride (2.9 g, 0.041 mol) in ethanol (20 mL) was added dropwise a solution of sodium carbonate (4.3 g, 0.041 mol) in water (25 mL). The mixture was heated at reflux for 3 hours. The mixture was concentrated in vacuo to remove the ethanol and the aqueous residue was extracted with ethyl acetate. The organic phase was dried (MgSO4), filtered and concentrated in vacuo to give 3,3-dimethylcyclohexanone oxime as a yellow oil. This material was used without further purification.

1. temperatureThe mixture was heated
2. temperatureat reflux for 3 hours
3. concentrationThe mixture was concentrated in vacuo
4. customto remove the ethanol
5. extractionthe aqueous residue was extracted with ethyl acetate
6. dry with materialThe organic phase was dried (MgSO4)
7. filtrationfiltered
8. concentrationconcentrated in vacuo