HCID 22319133, compound → (6-Methoxypyridin-3-yl)(pyridin-2-yl)methanone

HRID 547735Notes

Reaction equation

HRID 547735 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[OH:10])=[CH:5][N:4]=1>CC(C)=O.[O-2].[O-2].[Mn+4]>[N:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[C:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[N:4][CH:5]=1)=[O:10]

Participants

4

Reactant 1

HCID 22319133HCID 22319133, compound

Product 1

HCID 22319071(6-Methoxypyridin-3-yl)(pyridin-2-yl)methanoneYield 97.3%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 180AcetoneSolvent

Procedure

To a solution of 0.83 g of α-(2-methoxypyridin-5-yl)-2-pyridinemethanol in 20 ml of an acetone was added 1.70 g of activated manganese dioxide, followed by vigorously stirring at room temperature for 30 minutes. The resulting precipitates were filtered off and washed with acetone. Then, the filtrate was concentrated, to give 0.80 g of the title compound as a white solid.

Workup

  1. customThe resulting precipitates
  2. filtrationwere filtered off
  3. washwashed with acetone
  4. concentrationThen, the filtrate was concentrated

Sources & evidence

ORD record
ord-2c3d9b86e2284e49b1ee912fbb5f1ef0
Source dataset
uspto-grants-2011_05
Patent number
US07939549B2

Reaction notes

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