HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 2-(3,5-Dichloro-phenyl)-2-methyl-propionyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 2-(3,5-Dichlorophenyl)-2-methylpropanoic acid | HCID 58990719 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 2-(3,5-Dichloro-phenyl)-2-methyl-propionyl chloride | HCID 11528941 | — |
Reaction Steps
To a solution of 8.3 g (35.6 mmol) 2-(3,5-dichloro-phenyl)-2-methyl-propionic acid in 80 ml CH2Cl2 and 4 drops DMF 6.1 ml (71.2 mmol) oxalyl chloride was added at 0° C. and the resulting mixture stirred for 12 h After evaporation of the solvent 8.3 g (93%) 2-(3,5-dichloro-phenyl)-2-methyl-propionyl chloride was obtained as a light yellow oil, which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07939533B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-e373941a939744c9a567b4a85d643643 |
| Source note | uspto-grants-2011_05 |