Dichloromethane → 2-(3,5-Dichloro-phenyl)-2-methyl-propionyl chloride

HRID 547752Notes

Reaction equation

HRID 547752 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([CH3:14])([CH3:13])[C:10](O)=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1.C(Cl)[Cl:16]>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([CH3:14])([CH3:13])[C:10]([Cl:16])=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 589907192-(3,5-Dichlorophenyl)-2-methylpropanoic acid

Product 1

HCID 115289412-(3,5-Dichloro-phenyl)-2-methyl-propionyl chloride

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Procedure

To a solution of 8.3 g (35.6 mmol) 2-(3,5-dichloro-phenyl)-2-methyl-propionic acid in 80 ml CH2Cl2 and 4 drops DMF 6.1 ml (71.2 mmol) oxalyl chloride was added at 0° C. and the resulting mixture stirred for 12 h After evaporation of the solvent 8.3 g (93%) 2-(3,5-dichloro-phenyl)-2-methyl-propionyl chloride was obtained as a light yellow oil, which was used without further purification.

Workup

  1. customAfter evaporation of the solvent 8.3 g (93%) 2-(3,5-dichloro-phenyl)-2-methyl-propionyl chloride
  2. customwas obtained as a light yellow oil, which
  3. customwas used without further purification

Sources & evidence

ORD record
ord-e373941a939744c9a567b4a85d643643
Source dataset
uspto-grants-2011_05
Patent number
US07939533B2

Reaction notes

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