反应详情

1-Bromomethyl-3-nitro-benzene (455 mg, 2.11 mmol), 4′,5′-difluoro-2′-methoxy-biphenyl-4-ol (0.5 g, 2.11 mmol), and dried, finely ground potassium carbonate (363 mg, 2.63 mmol) in 30 mL acetone were refluxed under argon for 16 hrs similar to 2,4-difluoro-4′-(3-nitro-benzyloxy)-biphenyl above. The crude product was purified by trituration with 5% ethyl acetate in hexanes to yield 0.31 g (38%) of 4,5-difluoro-2-methoxy-4′-(3-nitro-benzyloxy)-biphenyl. LC-MS (ES) calculated for C20H15F2NO4, 371.34; found m/z 370 [M−H]−.

1. customThe crude product was purified by trituration with 5% ethyl acetate in hexanes