反应详情

1-Bromomethyl-3-nitro-benzene (0.9 g, 4.2 mmol), 2′,4′,5′-trifluoro-biphenyl-4-ol (1.15 g, 4.2 mmol), and dried, finely ground potassium carbonate (725 mg, 5.25 mmol) in 40 mL acetone were refluxed under argon for 19 hrs similar to 2,4-difluoro-4′-(3-nitro-benzyloxy)-biphenyl above. The crude product was purified by flash chromatography with 0-6% ethyl acetate in hexanes to yield 0.71 g (47%) of 2,4,5-trifluoro-4′-(3-nitro-benzyloxy)-biphenyl. LC-MS (ES) calculated for C19H12F3NO3, 359.31; found m/z 358 [M−H]−.

1. customThe crude product was purified by flash chromatography with 0-6% ethyl acetate in hexanes