Hydrochloric Acid → N-[5-(Piperidin-4-ylamino)-pyridin-2-yl]-acetamide dihydrochloride

HRID 547899Notes

Reaction equation

HRID 547899 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:16]=[N:17][C:18]([NH:21][C:22](=[O:24])[CH3:23])=[CH:19][CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25]>O1CCOCC1>[ClH:25].[ClH:25].[NH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:24])[CH3:23])=[N:17][CH:16]=2)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 671965384-(6-Acetylamino-pyridin-3-ylamino)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 67195991N-[5-(Piperidin-4-ylamino)-pyridin-2-yl]-acetamide dihydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 4-(6-acetylamino-pyridin-3-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (1.20 g, 3.59 mmol) in dioxane (20 mL) and 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 235.3 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-b2cc4ee9add24b869684364e6710374c
Source dataset
uspto-grants-2011_05
Patent number
US07939661B2

Reaction notes

Loading…