反应详情

To a solution of 5-(2-hydroxy)ethylthioimidazo[1,2-a]pyridine (9.71 g, 50 mmoles) and triethylamine (10.5 ml, 75.3 mmoles) in methylene chloride (300 ml) was added methanesulfonyl chloride (4.26 ml, 55 mmoles) under ice-cooling with stirring and the mixture was stirred under ice-cooling for 2 hours. The reaction mixture was washed in turn with aqueous saturated sodium bicarbonate and saturated saline and dried over anhydrous magnesium sulfate. Then, the solvent was distilled off to obtain 13.6 g of the desired product (quantitative, brown oily product).

1. temperaturecooling
2. stirringthe mixture was stirred under ice-
3. temperaturecooling for 2 hours
4. washThe reaction mixture was washed in turn with aqueous saturated sodium bicarbonate and saturated saline
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationThen, the solvent was distilled off