Hydrochloric Acid → HCID 67197529, compound

HRID 547909Notes

Reaction equation

HRID 547909 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][N:18]=[CH:17][C:16]=2[F:21])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[ClH:22].[F:21][C:16]1[CH:17]=[N:18][CH:19]=[CH:20][C:15]=1[NH:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67197045HCID 67197045, compound

Product 1

HCID 67197529HCID 67197529, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 4-(3-fluoro-pyridin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.16 g, 0.54 mmol) in dioxane (10 mL) and 4 M HCl in dioxane (10 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 196.3 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-51a4660a273f45f2ba0e931f2b441d9e
Source dataset
uspto-grants-2011_05
Patent number
US07939661B2

Reaction notes

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