反应详情

A solution of 5-[2-(methylsulfonyloxy)etylthio]imidazo[1,2-a]pyridine (2.18 g, 8 mmoles), triethylamine (2.24 ml, 16 mmoles) and a 40% methylamine-methanol solution (20 ml) in chloroform (20 ml) was heated at reflux for 3 hours. The reaction mixture was washed with 3N NaOH and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was purified by column chromatography [eluent: methanol/chloroform (1:10)] to obtain 781 mg of the desired product (47.1%, light brown oily product).

1. temperatureat reflux for 3 hours
2. washThe reaction mixture was washed with 3N NaOH
3. dry with materialdried over anhydrous magnesium sulfate
4. distillationAfter the solvent was distilled off
5. customthe residue was purified by column chromatography [eluent: methanol/chloroform (1:10)]