反应详情

A mixture of 6.20 g (26.6 mmol) of 4-chloro-6-nitro-quinoline-3-carbonitrile and 8.00 g (31.9 mmol) of 3,4-dibromoaniline in 160 mL of ethanol was refluxed under N2 for 5 h. Saturated sodium bicarbonate was added and volatile material was removed. The residue was slurried with hexane, collected, washed with hexane and water and dried. The insoluble material was repeatedly extracted with boiling ethyl acetate and the solution was then filtered through silica gel. The solvent was removed to give 3.80 g of green solid: mass spectrum (electrospray, m/e): M+H 449.

1. temperaturewas refluxed under N2 for 5 h
2. customvolatile material was removed
3. customcollected
4. washwashed with hexane and water
5. customdried
6. extractionThe insoluble material was repeatedly extracted with boiling ethyl acetate
7. filtrationthe solution was then filtered through silica gel
8. customThe solvent was removed